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ANTICORPS ARTIFICIEL PRODUIT À L'AIDE D'UNE SÉQUENCE PARTIELLE DE PROTÉINE ÉNOLASE ISSUE DE PLASMODIUM FALCIPARUM, ET SON PROCÉDÉ DE PRODUCTION
专利权人:
NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY;国立大学法人 群馬大学;NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE;国立研究開発法人国立国際医療研究センター
发明人:
OKU, Hiroyuki,奥 浩之,KANO, Shigeyuki,狩野 繁之,YANO, Kazuhiko,矢野 和彦,奥 浩之,狩野 繁之,矢野 和彦
申请号:
JPJP2015/083437
公开号:
WO2016/084944A1
申请日:
2015.11.27
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
Provided is a physiologically active peptide which comprises a partial amino acid sequence of enolase originated from Plasmodium falciparum and which has a molecular structure that meets the standards set for the production of GMP. A peptide having such a structure that two peptide molecules each comprising (i) an amino acid sequence A01-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-A02 (SEQ ID NO: 1) or (ii) an amino acid sequence A03-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-Lys-Ser-Leu-Val-Lys-Thr-A04 (SEQ ID NO: 2) are lined to a liker peptide represented by (iii) Lys-A05-Cys-A06 in such a manner that the two peptide molecules can be arranged in a biantennary form through amide bonds between carboxyl terminal of the two peptide molecules and two amino groups in a Lys residue in the linker peptide. Preferably, the peptide has a dimerized structure, in which the peptides are dimerized through an S-S bond formed between a Cys residue in the sequence for the linker peptide in one of the peptides and a Cys residue in the sequence for the linker peptide in the other of the peptides. (In the amino acid sequences (i), (ii) and (iii), each of A01 to A06 represents a molecule composed of an arbitrary number, including 0, of amino acid residues.)Cette invention concerne un peptide physiologiquement actif qui comprend une séquence d'acides aminés partielle d'énolase issue de Plasmodium falciparum et ayant une structure moléculaire conforme aux normes établies pour la production selon GMP. Le peptide selon l'invention a une structure telle que deux molécules peptidiques comprenant chacune (i) une séquence d'acides aminés A01-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr- Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-A02 (SEQ ID No : 1) ou (ii) une séquence d'acides aminés A03-Ala-Ser-Glu-Phe-Tyr-Asn-Ser-Glu-Asn-Lys-Thr-Tyr-Asp-Leu-Asp-Phe-Lys-Thr-Pro-Asn-Asn-Asp-Lys-Ser-Leu-Val-Lys-Thr-A04 (S
来源网站:
中国工程科技知识中心
来源网址:
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