The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 viruse) strains which have been derived from the wild-type dengue-1 strain 16007 by passaging on PDK and sanitization on Vero cells. The invention further relates to a vaccine composition which comprises a VDV1 strain.本發明關於減毒活VDV1(自VERO衍生之登革熱血清型1病毒)病毒株,其係藉由在PDK上傳代及在Vero細胞上淨化而衍生自野生型登革熱1病毒株16007。本發明進一步關於一種包含VDV1病毒株的疫苗組成物。