The invention relates to a method for inducing protection against the 4 serotypes of dengue fever in a patient, comprising: (a)the administration of a monovalent vaccine comprising a vaccinal virus of a first serotype of dengue fever, and (b)the administration of a tetravalent vaccine comprising vaccinal viruses ofthe four serotypes of dengue fever, in which administration (b) is made between at least 30 days and not more than 12 months following the first administration (a).本發明係關於在患者體內誘發針對4種登革熱血清型之保護之方法，其包含：(a)投與一單價疫苗，該單價疫苗包含登革熱第一血清型之疫苗病毒，及(b)投與一四價疫苗，該四價疫苗包含登革熱四個血清型之疫苗病毒，其中投與(b)係在投與(a)之後至少30天與不超過12個月之間進行。
