The invention relates to a method to induce a protection against the 4 dengue serotypes in a patient, comprising: (a) the administration of a monovalent vaccine comprising a vaccine virus of a first dengue serotype, and (b) the administration of a tetravalent vaccine comprising vaccine viruses of the four serotypes of dengue, wherein the administration (b) is implemented at least 30 days to at most 12 months after the first administration (a).
