CASE WESTERN RESERVE UNIVERSITY;THE CLEVELAND CLINIC FOUNDATION
发明人:
Victor L. Perez,Joe G. Hollyfield,Robert G. Salomon
申请号：
US16534752
公开号：
US20200000070A1
申请日:
2019.08.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.
