Martin Friedlander,Atsushi Otani,Karen Da Silva,Stacey (Hanekamp) Moreno
申请号：
US11788973
公开号：
US08900567B2
申请日:
2007.04.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method of preserving cone cells in the eye of a mammal suffering from a retinal degenerative disease comprises isolating from the bone marrow of the mammal a lineage negative hematopoietic stem cell population that includes endothelial progenitor cells, transfecting cells from the stem cell population with a gene that operably encodes an antiangiogenic fragment of human tryptophanyl tRNA synthetase (TrpRS), and subsequently intravitreally injecting the transfected cells into the eye of the mammal in an amount sufficient to inhibit the degeneration of cone cells in the retina of the eye. The treatment may be enhanced by stimulating proliferation of activated astrocytes in the retina using a laser.
