DUDLER THOMAS,GOMBOTZ WAYNE R.,PARENT JAMES BRIAN,TEDFORD CLARK E.,KAVLIE ANITA,HAGEMANN URS BEAT,REIERSEN HERALD,KIPRIJANOV SERGEJ
申请号：
NZ61748712
公开号：
NZ617487A
申请日:
2012.05.04
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated human monoclonal antibody, or antigen binding fragment thereof, that binds to human MASP-2 and inhibits MASP-2 dependent complement activation, comprising: (i) a heavy chain variable region comprising three complementary determining regions CDR-H1, CDR-H2 and CDR-H3； and (ii) a light chain variable region comprising three CDRs CDR-L1, CDR-L2 and CDR-L3, wherein； CDR-H1 comprises an amino acid sequence as set forth in RGKMG； CDR-H2 comprises an amino acid sequence as set forth in LAHIFSSDEKSYRTSL； CDR-H3 comprises an amino acid sequence set forth as YYCARIRX wherein X at position 8 is A or R； and wherein CDR-L1 comprises an amino acid sequence as set forth in GXKLGDKXAY, wherein X at position 2 is D or E and wherein X at position 8 is F or Y； CDR-L2 comprises an amino acid sequence as set forth in DXXRPSG, wherein X at position 2 is N or K and wherein X at position 3 is K or Q； and CDR-L3 comprises an amino acid sequence set forth as AWDSSTAVF, and wherein the isolated antibody inhibits MASP-2 dependent complement activation.
