Dudler Thomas,Gombotz Wayne R.,Parent James Brian,Tedford Clark E.,Kavlie Anita,Hagemann Urs Beat,Reiersen Herald,Kiprijanov Sergej
申请号：
NZ71522612
公开号：
NZ715226A
申请日:
2012.05.04
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is an isolated human monoclonal antibody, or antigen binding fragment thereof, that binds to human MASP-2 and inhibits MASP-2 dependent complement activation, wherein the antibody or antigen-binding fragment thereof comprises: a) a heavy chain variable region comprising three complementary determining regions CDR-H1, CDR-H2 and CDR-H3； and b) a light chain variable region comprising three CDRs CDR-L1, CDR-L2 and CDR-L3； wherein: CDR-H1 comprises an amino acid sequence as set forth in SEQ ID NO:29； CDR-H2 comprises an amino acid sequence as set forth in SEQ ID NO:33； CDR-H3 comprises an amino acid sequence as set forth in SEQ ID NO:38； CDR-L1 comprises an amino acid sequence as set forth in SEQ ID NO:92； wherein X at position 2 is N or D and wherein X at position 4 is I or L and whrein X at position 6 is S or K and wherein X at position 8 is N or R CDR-L2 comprises an amino acid sequence as set forth in SEQ ID NO:49； CDR-L3 comprises an amino acid sequence as set forth in SEQ ID NO:94； wherein X at position 4 is T or I and wherein X at position 5 is T or A.
