Patrick F. Desmond,Robert J. Bloch,Mark A. Rizzo,Joaquin Muriel,Michele L. Markwardt
申请号：
US15016086
公开号：
US20160228502A1
申请日:
2016.02.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Embodiments of the disclosure concern methods and compositions related to the small Ankyrin 1 (sAnk1) protein and its role as a regulatory protein in at least muscle cells. In particular embodiments, its expression and/or activity are modulated with one or more compositions. In specific embodiments, compositions such as nucleic acids that inhibit expression of sAnk1 are utilized for a variety of methods, whereas in other embodiments compositions such as polypeptides, peptides, or sAnk1-encoding nucleic acids that enhance sAnk1 levels are utilized for certain methods.
