A one-time use cartridge for a CT or MRI syringe has a syringe body coupled to an adapter by flanges that are trapped by a locking tooth supported as part of a groove in a unitary adapter. One-time use is enhanced with one-way valves associated with the forward end of the syringe body. The one-way valves have coaxial inner and outer members with reversed roles for fluid inflow and outflow tubing connections. The valves operate under positive and negative pressure generated by the syringe piston.
