A syringe adapter with a ball-typed valve has a base, a dosing tube mounted around the base and a resilient valve mounted in the base and the dosing tube. The base has a guiding groove and an inner liquid channel communicating with each other, as well as an exhaust channel. Liquid medicine injected into the syringe adapter flows through the guiding groove and causes the inner liquid channel to be injected into a patients body. The liquid medicine remaining in the split is cleaned when cleaning fluid is injected to clean the syringe adapter. Air in the syringe adapter flows out through the exhaust channel and is not injected into the patients body, so the patient is free from pain. Furthermore, elements and assembling processes of the syringe adapter are simplified and manufacturing cost of the syringe adapter is lowered.