TROIANO, Greg;WANG, Hong;MCGREGOR, Caroline;BIND THERAPEUTICS, INC.;LAM, Michael, H.;MERCK SHARP & DOHME CORP.;FIGUEIREDO, Maria;SUNG, Young Ho
发明人:
SUNG, Young Ho,TROIANO, Greg,WANG, Hong,FIGUEIREDO, Maria,LAM, Michael, H.,MCGREGOR, Caroline
申请号：
USUS2015/020086
公开号：
WO2015/142605A3
申请日:
2015.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[l,2,4]-triazolo-[3,4-fJ[1,6]- naphthyridin-3-one (Compound A), or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles.The nanoparticle comprises about 50 to about 99.8 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the total amount of poly(ethylene)glycol in the nanoparticle is about 10 to about 30 weight percent poly(ethylene)glycol and about 0.2 to about 30 weight percent of Compound A.L'invention concerne des nanoparticules polymères qui comprennent 8-[4-(1-amino-cyclobutyl)phényl]-9-phényl-2H-[1,2,4]-triazolo-[3,4-f][1,6]-naphtyridine-3-one, ou un sel pharmaceutiquement acceptable de celui-ci, et des procédés de fabrication et d'utilisation de telles nanoparticules.
