The present invention is related to the usage of Antrodia cinnamomea fruit body derivatives. The fruit body derivatives comprise acetic acid extract, acetic ether extract and Antrocamphin A. The acetic acid extract, acetic ether extract and Antrocamphin A can reduce the expression of iNOS and COX-2 and therefore inhibit the production of proinflammatory molecules.本發明關於樟芝子實體衍生物於抗發炎之用途,該子實體衍生物包括乙醇萃取物、乙酸乙酯萃取物和Antrocamphin A。該乙醇萃取物、乙酸乙酯萃取物和Antrocamphin A能降低一氧化氮合成酶或第二型環氧酶的表現而抑制促發炎分子的產生。