The present invention relates to a composition comprising an amount of protein A (PA) for use in treating an immune dysfunction in a subject with or at risk of an immune dysfunction, for use in reducing an inflammatory response in a subject with or at risk of an inflammatory response, for use in treating inflammation in a subject with or at risk of inflammation, or for use in inhibiting rejection of a transplanted cell, tissue or organ in a subject, wherein the amount is a dose of 50 pg/kg to 50 µg/kg, a single dose of 5000 pg/kg to 50,000 pg/kg or a single dose of 50 pg/kg to 50 µg/kg.
