Provided are antibodies, including functional antibody fragments, that specifically bind to discoidin domain receptors (DDRs), and in particular to DDR1 proteins, as well as uses and method of using such antibodies, including in the detection, diagnosis and treatment of diseases and conditions associated with DDR1.本發明所提供者係抗體,包括專一性結合至盤狀網柱細胞黏菌素結構域受體(discoidin domain receptor(DDR))、特別是結合至DDR1蛋白質的功能性抗體片段,以及利用該等抗體的用途及方法,包括偵測、診斷及治療與DDR1有關之疾病與病況。