The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor. Pharmaceutical compositions comprising the bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the bispecific antigen binding proteins to ameliorate or treat conditions associated with the two receptors, such as chronic pain, migraine, and cluster headache, are also described.本發明係關於能夠結合至人類CGRP受體及人類PAC1受體之雙特異性抗原結合蛋白質。亦揭示包含雙特異性抗原結合蛋白質之醫藥組成物以及用於產生該等醫藥組成物之方法。亦描述使用雙特異性抗原結合蛋白質來改善或治療與兩種受體相關聯的病狀(諸如慢性疼痛、偏頭痛及叢集性頭痛)之方法。
