APPUKUTTAN, PRASAD,GEORGE, SHYLA,UJJINAMATADA, RAVI KOTRABASAIAH,NARASINGAPURAM ARUMUGAN, KARTHIKEYAN,RAJAGOPALAN, SRINIVASAN,LINNANEN, TERO
申请号：
PE2015002104
公开号：
PE20160115A1
申请日:
2014.04.03
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
A formulation compound (I) is described,In cancer treatment, Z1 is n, Z2 is ch or Z1 is ch, Z2 is n or Z1, Z2 is n or Z1, Z2 is n, Z is ch or N, a is phenyl ring, etc. R1 is C1-C7 tar, etc. R2 is h, halogenated ring, etc. R3 is h, halogenated ring, etc. 4-difluorophenyl-n - (1-methyl-1h-pirazol-3-il) - 6 - (5 - (1-methyl-1h-pirazol-4-il) - 1H benzo [D] imidazol-1-il) pyridine-2-amine； N - (4 - (2,4-difluorophenyl) - 6 - (5 - (1-methyl-1h-pirazol-4-il) - 1h-pyrSe describe un compuesto de la formula (I), util en el tratamiento del cancer； donde Z1 es N； Z2 es CH o Z1 es CH y Z2 es N o Z1 y Z2 son N； Z es CH o N； A es anillo fenilo, etc. R1 es alquilo C1-C7, etc. R2 es H, halogeno, etc. B es anillo heterociclico, etc. R3 es H, halogeno, etc. R4 es H, halogeno, etc. R5 es H etc. Los compuestos preferidos son: 4-(2,4-difluorofenil)-N-(1-metil-1H-pirazol-3-il)-6-(5-(1-metil-1H-pirazol-4-il)-1H-benzo[d]imidazol-1-il)piridin-2-amina； N-(4-(2,4-difluorofenil)-6-(5-(1-metil-1H-pirazol-4-il)-1H-benzo[d]imidazol-1-il)piridin-2-il)ciclopropansulfonamida
