LADNER, ROBERT C.,LEY, ARTHUR C.,HIRANI, SHIRISH,WILLIAMS, ANTHONY,DE SIMONI, MARIA GRAZIA,BERGAMASCHINI, LUIGI,BLAIR, HENRY,BECK, THOMAS
申请号：
CA2581680
公开号：
CA2581680C
申请日:
2005.09.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Methods, kits and compositions are described that include a non-naturallyoccurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia,e.g., ischemia associated with perioperative blood loss and cerebral ischemia,the onset of systemic inflammatory response, and/or reperfusion injury, e.g.,reperfusion injury associated with cerebral ischemia or a focal brainischemia, e.g., in patients subjected to invasive surgical procedures,especially procedures requiring cardiopulmonary bypass. Methods are describedfor preventing or reducing ischemia, e.g., cerebral ischemia, and/orreperfusion injury, e.g., reperfusion injury associated with cerebralischemia, in a patient by administering a kalliekrein inhibitor.
