The present invention relates to low concentration synergistic Xenon-Argon gas mixtures argon for use in a method for preventing and/or treating ischemic insults, wherein—;the volume proportion of xenon is between 5 and 20%;—;the volume proportion of argon is between 5 and 20%; and—;the pharmaceutical composition further comprises a gas complement to reach 100% volume proportion;—;the method includes comprises restoration of blood flow and the gas mixture is administered to the patient before, during, or after blood flow restoration.