The present invention relates to low concentration synergistic Xenon-Argon gas mixtures argon for use in a method for preventing and/or treating ischemic insults, wherein - the volume proportion of xenon is between 5 and 20 %; - the volume proportion of argon is between 5 and 20 %; and - the pharmaceutical composition further comprises a gas complement to reach 100 % volume proportion; - the method includes comprises restoration of blood flow and the gas mixture is administered to the patient before, during, or after blood flow restoration.