AMELIORATION DE L'ANTICORPS HUMANISE ANTI-INTEGRINE A9 HUMAINE

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专利权人:

JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE;ASTELLAS PHARMA INC.

发明人:

UEHARA, KENJI,HIGUCHI, HIROFUMI,NAKASHIMA, TOSHIHIRO,ISHIKAWA, DAISUKE,YAMAMOTO, NOBUCHIKA,FUJITA, HIROTADA,SAKAI, FUMIHIKO

申请号：

CA2711882

公开号：

CA2711882C

申请日:

2009.01.09

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Disclosed is a humanized anti-human .alpha. 9-integrin antibody havingimproved activities and/or physical propertiescompared with a donor mouse anti-human .alpha. 9-integrin antibody.Specifically disclosed are: a humanized anti-human .alpha. 9-integrinantibody having a heavy-chain variable region comprising the amino acidsequence depicted in SEQ ID NO: 11 and a light-chainvariable region comprising the amino acid sequence depicted in SEQ ID NO: 17；a humanized anti-human .alpha. 9-integrin antibodyhaving a heavy-chain variable region comprising the amino acid sequencedepicted in SEQ ID NO: 13 and a light-chain variableregion comprising the amino acid sequence depicted in SEQ ID NO: 17； and ahumanized anti-human .alpha. 9-integrin antibody havinga heavy-chain variable region comprising the amino acid sequence depicted inSEQ ID NO: 15 and a light-chain variable regioncomprising the amino acid sequence depicted in SEQ ID NO:9. Also disclosed isa means for preventing or treating a disease ofwhich human .alpha. 9-integrin is involved in the development of the diseasecondition, which utilizes the antibody.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/