The present invention relates to high drug load, controlled release pharmaceutical composition comprising Valproic acid or its pharmaceutically acceptable derivatives, esters, amides, salts, solvates, polymorphs, enantiomers or mixtures thereof wherein, the granules used for the composition do not exhibit sticking during compression. Approaches as cited in the prior arts involve use of specialized excipients or controlled atmospheric conditions to overcome sticking tendency of the drug. The present invention offers a simple, reproducible, and cost-effective manufacturing process for preparation of a controlled release pharmaceutical dosage form comprising an effective amount of Divalproex sodium.
