Popov, Alexey,Enlow, Elizabeth M.,Bourassa, James,Gardner, Colin R.,Chen, Hongming,Ensign, Laura M.,Lai, Samuel K.,Yu, Tao,Hanes, Justin,Yang, Ming
申请号：
AU2013256130
公开号：
AU2013256130A1
申请日:
2013.05.03
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Compositions with improved particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions may include modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications.
