Paul R. Fatheree;Brooke Olson;Robert Murray McKinnell;Seok-Ki Choi
发明人:
Seok-Ki Choi,Paul R. Fatheree,Robert Murray McKinnell,Brooke Olson
申请号:
US13685148
公开号:
US08664254B2
申请日:
2012.11.26
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention is directed to compounds having the formula:wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.