THE UNITED STATES OF AMERICA, AS REPREESENTED BY THE SECRETARY, AGRICULTURE;INSTITUT PASTEUR;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
发明人:
John P. BANNANTINE,Gilles ETIENNE,Sylvie BAY,Franck BIET
申请号：
US16470962
公开号：
US20200024307A1
申请日:
2017.12.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
