GRAS ESCARDO, JORDI,LLENAS CALVO, JESUS,RYDER, HAMISH,ORVIZ DIAZ, PIO
申请号：
RSP20090197
公开号：
RS50787B2
申请日:
2005.05.31
申请国别(地区):
RS
年份:
2018
代理人:
摘要：
Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). ACTIVITY : Antiasthmatic Respiratory-Gen. Antiinflammatory. MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor Muscarinic receptors antagonist Leukotriene-D4 antagonist Neurokinin-1- receptor antagonist Epidermal growth factor receptor kinase inhibitor Beta-2 agonist p38 Kinase inhibitor.
