PROBLEM TO BE SOLVED: To provide compositions including a transnorsertraline or a pharmaceutically acceptable salt thereof, a serotonin receptor 1A antagonist or a pharmaceutically acceptable salt or solvate thereof, and a serotonin receptor 1A agonist or a pharmaceutically acceptable salt or solvate thereof.SOLUTION: The present invention provides: compositions including (1S,4R)-transnorsertraline, and serotonin receptor 1A antagonist such as pindolol and lecozotan, a serotonin receptor 1A agonist such as buspirone and eltoprazine； and a method of treating neurological disorders such as depression, cognitive deficits, fibromyalgia, pain, and sleep related disorders by using the compositions.【課題】トランスノルセルトラリン、又はその医薬として許容し得る塩、及びセロトニン受容体1A拮抗剤、又はその医薬として許容し得る塩、溶媒和物、更にセロトニン受容体1A作動剤、又はその医薬として許容し得る塩、溶媒和物含む組成物の提供。【解決手段】(1S,4R)-トランスノルセルトラリン、及びピンドロール、レコゾタン等のセロトニン受容体1A拮抗剤、更にブスピロン、エルトプラジン等のセロトニン受容体1A作動剤を含む組成物、及びこれを用いる、うつ病、認知障害、線維筋痛症、疼痛及び睡眠関連疾患等の神経疾患の治療方法。【選択図】なし
