WOODSIDE DARREN G,VANDERSLICE PETER,MARATHI UPENDRA K
申请号：
IN201717040886
公开号：
IN201717040886A
申请日:
2017.11.15
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Small molecule integrin ligand mimetics facilitate integrin ligand interactions which maybe used to prepare vaccines adoptive cell therapies immunotherapies for cancer and a variety of other conditions. As integrin mediated cell cell interactions are critical to antigen presentation and effector cell killing increasing the efficiency of integrin receptor ligand interactions will stabilize the immune synapse and improve effector functions. Compositions and methods including the mimetics enhance: (1) the priming of vaccines (including but not limited to cancer vaccines) (2) cytolytic activity of adoptive cell therapies (including but not limited to d cells CTLs NK iNKT) (3) immunotherapies (including but not limited to negative checkpoint blockage strategies such as anti CTLA 4 and anti PD 1) and (4) biologic therapies (including but not limited to trastuzumab and rituxamab) whereby the mechanism of action includes antibody dependent cellular cytotoxicity (ADCC).
