Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling

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专利权人:

The Board of Trustees of the Leland Standford Junior University

发明人:

Lynn, Rachel,Mackall, Crystal,Weber, Evan,Malhotra, Sanjay

申请号：

AU2018243571

公开号：

AU2018243571A1

申请日:

2018.03.30

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Provided herein are compositions and methods for preventing or reversing T cell exhaustion. In particular, the present invention relates to methods of preventing or reversing T cell exhaustion by exposing T cells experiencing T cell exhaustion to particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib), or by expanding genetically engineered T cells in the presence of particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/