METHODS OF TREATING T CELL EXHAUSTION BY INHIBITING OR MODULATING T CELL RECEPTOR SIGNALING

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专利权人:

THE BOARD OF TRUSTEES OF THE LE-LAND STANDFORD JUNIOR UNIVERSITY

发明人:

Rachel LYNN,Crystal MACKALL,Evan WEBER,Sanjay MALHOTRA

申请号：

US16499762

公开号：

US20200101108A1

申请日:

2018.03.30

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are compositions and methods for preventing or reversing T cell exhaustion. In particular, the present invention relates to methods of preventing or reversing T cell exhaustion by exposing T cells experiencing T cell exhaustion to particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib), or by expanding genetically engineered T cells in the presence of particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib).

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中国工程科技知识中心

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http://www.ckcest.cn/home/