SHANGHAI INSTITUTE OF MATERIA MEDICA; CHINESE ACADEMY OF SCIENCES
发明人:
Ao Zhang,Zehong Miao,Na Ye,Xiajuan Huan,Zilan Song,Chuanhuizi Chen,Yi Chen,Jian Ding
申请号：
US14418705
公开号：
US09255106B2
申请日:
2013.07.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided is a piperazinotriazole compound represented by general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer or hydrate thereof. Also provided are a pharmaceutical composition comprising the compound, a method for preparing the compound and a method of use thereof as a high-selectivity poly(adenosine diphosphate-ribose)polymerase-1 (PARP-1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
