This invention the useful new 5 oxazolidine 2 on displacement 1,3,8 triazaspiro [4.5] designates the Deccan 4 on derivative as purpose in remedy of the disease and the condition where the ORL 1 receptor lies between. This invention furthermore, designates the medicine constituent, and the ORL 1 mediation disease and remedies condition the manner which include process and the aforementioned derivative which prepare the aforementioned derivative as purpose.本発明は、ORL-1受容体が介在する疾患及び症状の治療に有用な新規5-オキサゾリジン-2-オン置換1,3,8-トリアザスピロ[4.5]デカン-4-オン誘導体を目的とする。本発明は更に、前記誘導体を調製するプロセス、前記誘導体を含む医薬組成物、及びORL-1媒介疾患及び症状を治療する方法を目的とする。
