Problem to be solved: to provide an operation method of an endoscope system and an endoscope system in which a plurality of light sources for independently emitting light of different colors are independently emitted by a plurality of light sources so that the observation object can be observed in the same manner as when the continuous spectral light is used for illumination light.Solution: V, Mg, y, y, B, y, y, y, G, G, G, G, G, G, G, G, G, G, G, G, G, and G, respectively. The ratio of the light amount integral value for each color that can be received by the e pixel and the G pixel is matched.Selection diagram【課題】互いに異なる色の光を独立して発光する複数の光源を用いて連続スペクトル光を照明光に用いた場合とほぼ同様に観察対象を観察可能にする内視鏡システム及び内視鏡システムの作動方法を提供する。【解決手段】V光、B光、G光、R光を、Cy画素、Mg画素、Ye画素、G画素でそれぞれ受光して得る色毎の光量積分値と光量比Cv:Cb:Cg:Crとに基づいて算出される値を、キセノンランプの連続スペクトル光26を、Cy画素、Mg画素、Ye画素、G画素でそれぞれ受光して得る色毎の光量積分値の比率に一致させる。【選択図】図14