Avery D. Posey;The Trustees of the University of Pennsylvania;Sonia Guedan Carrio;Carl H. June;NOVARTIS AG;John Scholler
发明人:
Carl H. June,Sonia Guedan Carrio,Avery D. Posey,John Scholler
申请号：
US15327794
公开号：
US20170209492A1
申请日:
2015.07.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4′ and CD8′ T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
