An animal targeting system includes a set of activation sensors, a set of deactivation sensors and a pharmaceutical delivery mechanism. A first activation sensor can detect a presence of a target animal at a first position. A second activation sensor can detect the presence of the target animal at a second position. A first deactivation sensor can detect a lack of presence of the target animal at a threshold height higher than an expected height of the target animal. A second deactivation sensor can detect a presence of a gap between an abdomen of the target animal and ground level. The pharmaceutical delivery mechanism ejects a pharmaceutical onto a coat of the target animal based on the detected presence of the target animal by the activation sensors and based on the lack of detection of characteristics inconsistent with the target animal by the deactivation sensors.