New azabiphenylaminobenzoic acid derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).本發明揭露新穎的具有式(I)之化學結構之氮雜聯苯胺基苯甲酸衍生物;以及其製備方法;包括其的醫藥組合物;以及其在療法中用作二氫乳清酸脫氫酶(DHODH)抑制劑的用途。