CARDOZO, Timothy,PAGANO, Michele,WU, Lily,GOLD, Leslie, I.
申请号：
USUS2013/065256
公开号：
WO2014/062811A3
申请日:
2013.10.16
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity. The ubiquitin proteasome system ("UPS") is essential for the turnover of almost all cellular proteins, maintaining homeostatic levels in normal cells while controlling levels of oncogenes and tumor suppressors in transformed cells.Cette invention concerne des compositions pharmaceutiques comprenant un composé et un excipient pharmaceutiquement acceptable. Linvention concerne également une méthode de traitement du cancer chez un sujet, des méthodes dinhibition de lactivité du complexe SCF-Skp2, ainsi quune méthode didentification des inhibiteurs de lactivité du complexe SCF-Skp2.
