БОРД ОФ РИДЖЕНТС; ДЗЕ ЮНИВЕРСИТИ ОФ ТЕХАС СИСТЕМ (US)
发明人:
ОЛСОН Эрик Н. (US),РУИДЖ Ева Ван (US),КУИЭТ Дэниел (US)
申请号：
RU2012129900/15
公开号：
RU2012129900A
申请日:
2010.12.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of treating or preventing myocardial ischemia in a subject in need thereof, comprising modulating expression or activity of one or more microRNAs that are listed in Tables 1 and 2, in subekta.2 heart cells. A method according to claim 1, wherein the one or more miRNAs selected from the group consisting of miR-15 family member, miR-21, miR-26a, let-7b, miR-199a, miR-214, miR-10a, miR-10b, miR-574, miR-320, miR-92a, miR-499, miR-101a, miR-101b, miR-125b, miR-126, miR-30 family member, miR-143, miR-145, miR-185, miR-34a, miR-1, miR-133, miR-210 and miR-29a-c.3. A method according to claim 2, wherein the modulation comprises administering to a subject an inhibitor of one or more miRNAs selected from the group consisting of miR-15 family member, miR-92a, miR-320, miR-21, miR-199a, miR- 499 and family member miR-30.4. A method according to claim 3, wherein the inhibitor of one or more micro-RNA is an antisense oligonucleotide or antagomir.5. A method according to claim 4, wherein the antisense oligonucleotide comprises a sequence that is at least partially complementary to a mature sequence of said one or more micro-RNK.6. A method according to claim 4, wherein the antisense oligonucleotide comprises at least one modification of the sugar moiety and / or ostova.7. A method according to claim 4, wherein the length of the antisense oligonucleotide is from about 8 to about 18 nukleotidov.8. A method according to claim 2, wherein the modulation comprises administering to the subject an agonist of one or more miRNAs selected from the group consisting of miR-126, miR-143, miR-210 and miR-29a-c.9. A method according to claim 8, wherein the agonist of one or more micro-RNA is a polynucleotide comprising a mature sequence of one or more micro-RNK.10. A method according to claim 9, wherein the agonist is expressed from an expression konstruktsii.11. A method according to claim 3 or 8, to1. Способ лечения или предупреждения ишемии миокарда у нуждающегося в этом субъекта,
