Micro-RNAs that control myosin expression and myofiber identity

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专利权人:

The University of Texas System;Board of Regents

发明人:

Van Rooij, Eva,Olson, Eric

申请号：

AU2008283794

公开号：

AU2008283794B2

申请日:

2008.07.31

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention relates to the identification of two microRNAs, miR-499and miR-208b, that repress fast skeletal muscle contractile protein genes.Expression of miR-499 and/or miR-208b can be used to repress fast fiber genesand activate slow fiber genes in the treatment of musculoskeletal disorders.Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiachypertrophy, myocardial infarction, and/or heart failure. Pharmaceuticalcompositions comprising antagonists and agonists of miR-499 and miR-208b functionare also disclosed.

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