БАУЭН Маюми Н. (US),ЛЮ Цзюнь (US),ПЕЙТЕЛ Анкит Р. (US)
申请号：
RU2012151500/15
公开号：
RU2012151500A
申请日:
2011.04.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A composition of substances containing a protein and a compound capable of reducing the viscosity of an aqueous composition containing said protein. The composition of substances according to claim 1, in which the protein is an antibody. The composition of substances according to claim 1, wherein said compound capable of reducing the viscosity of an aqueous composition containing said protein is selected from the group consisting of arginine-HCl, arginine succinate, arginine dipeptide, arginine tripeptide, polyarginine, homoarginine, 2-amino 3-guanidino-propionic acid, guanidine, ornithine, agmatine, guanidobutyric acid, urea, citrulline, N-hydroxy-L-nor-arginine, methyl nitroarginine ester, argininamide, arginine methyl ester, arginine ethyl ester, arginine ethyl ester, lysine ester , lysinamide, methyl ester of lysine, histidine, methyl ester of histidine, histamine, alanine, alaninamide, methyl ester of alanine, putrescine, cadaverine, spermidine, spermine and methionine. 4. The composition of substances according to claim 1, wherein said compound capable of reducing the viscosity of an aqueous composition containing said protein is selected from the group consisting of arginine-HCl, arginine succinate, homoarginine, agmatine, nitroarginine methyl ester, argininamide, methyl ester arginine, arginine ethyl ester, lysine methyl ester, alanine, putrescine, cadaverin, spermidine and spermine. 5. The composition of substances according to claim 3, wherein said compound capable of reducing the viscosity of said aqueous composition is present in a concentration of at least 10 mM. The composition of substances according to claim 3, in which the specified compound is capable of1. Композиция веществ, содержащая белок и соединение, способное уменьшать вязкость водного состава, содержащего указанный белок.2. Композиция веществ по п.1, в которой белок является антителом.3. Композиция веществ по п.1, в которой указанное соединение, способное уменьшать вязкость водного соста
