The present disclosure relates to a synergistic mixture of betamethasone valerate and tranilast combined with a transdermal gel using skin permeation enhancement for application in scars for reducing or preventing the abnormal scar formation, specially keloids and hypertrophic scars. The disclosed synergistic mixture may exhibit permeation enhancing properties. The transdermal gel may include a mixture of silicone, phosphatidylcholine, pracaxi oil, and seje oil one or more oils having essential fatty acids, behenic acid, oleic acid one or more skin lipids a butter having linoleic acid and linolenic acid and solvents as transdermal penetration enhancers.
