The invention relates to a transdermal microneedle unit and a transdermal microneedle drug delivery device comprising the transdermal microneedle unit. The transdermal microneedle unit comprises a plurality of sheets stacked with each, each the sheet having at least one through hole defined thereon and a barbule arranged at the peripheral of the through hole, wherein the through hole on one sheet is penetrated by the barbules of other sheets and the barbules being disposed separately to form at least one triangular pyramidal transdermal microneedle. The transdermal microneedle drug delivery device comprises a substrate, a transdermal microneedle unit, an union joint and an injection syringe.本發明係關於一種經皮微針管單元及其構成的經皮微針管投藥裝置。本發明之經皮微針管單元包含複數個互相重疊的薄片,每一薄片上至少具有一穿孔,該穿孔邊緣設置有一突刺,其中一薄片上的穿孔係供其餘的薄片上的突刺穿過,且該些突刺呈彼此分離排列形成至少一錐狀之經皮微針管。本發明之經皮微針管投藥裝置包含:基板、經皮微針管單元、轉接頭及注射針筒。10‧‧‧基板101‧‧‧中心區域103‧‧‧孔洞105‧‧‧孔槽20‧‧‧經皮微針管單元202‧‧‧經皮微針管226‧‧‧倒鉤30‧‧‧O型環40‧‧‧轉接頭42‧‧‧後端44‧‧‧中段46‧‧‧前端462‧‧‧凸柱464‧‧‧環狀凹槽
