A system for ultrasound-enhanced transscleral delivery of at least one drug to a target site in a intraocular space (1), the system comprising a signal generating unit (300) operationally connected to an ultrasound transducer (202) and a drug applicator (201), wherein the drug applicator comprises at least one space (800) hold the drug, is made from a low ultrasound attenuation material, is configured to provide low ultrasound loss coupling of the system to the sclera, and is configured to be mechanically coupled to the system and further configured to be coupled to the ultrasound transducer with low ultrasound loss. The signal generating unit and/or the ultrasound transducer are configured to emit an ultrasound wave form in at least one application cycle, the application cycle comprising at least one ultrasound emitting event with a time duration TA and a waiting period with a time duration TW.
