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稠合雜環化合物
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
TANIGUCHI, TAKAHIKO,谷口孝彦,谷口孝彥,YOSHIKAWA, MASATO,吉川真人,MIURA, KASEI,三浦佳世,HASUI, TOMOAKI,莲井智章,蓮井智章,HONDA, EIJI,本多荣治,本多榮治,IMAMURA, KEISUKE,今村圭佑,KAMATA, MAKOTO,鎌田信,KAMISAKI, HARUHI,上春阳
申请号:
TW100121762
公开号:
TW201213324A
申请日:
2011.06.22
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on.A compound represented by the formula (I):wherein ring A represents an optionally substituted 6-membered ring; any one or two of from Z1 to Z4 represents -N=, and the others represent -CH=;Y represents an oxygen atom, a sulfur atom, an optionally substituted methylene group or -NRc-;Rc represents a hydrogen atom, or a substituent; and R represents(1) a group represented by the formula:wherein R1 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted; L represents a sulfur atom, an oxygen atom, an optionally substituted methylene group, -CO-, -NRa-, -CH2O-, -NRaCOO-, -NRaCONRb-, -NRaCOCH2-, -NRaCO-,; Ra and Rb are the same or different and each represents a hydrogen atom, or an optionally substituted C1-6 alkyl group, or L and R1 in combination optionally form an optionally substituted bi- or tri-cyclic fused heterocyclic group; and ring B1 represents a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring or a pyridazine ring, each of which is optionally substituted; or(2) a group represented by the formula:wherein R2 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted; ring B2 represents a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring or a pyridazine ring, each of which is optionally substituted; and ring D represents an optionally further substituted 5- or 6-membered ring; or a salt thereof.本發明提供一種化合物,其具有抑制PDE之效果,以及一種有效作為預防或治療精神分裂症等之製劑。一種下式(I)表示之化合物或其鹽:其中,環A表示視需要經取代之6員環;選自Z1至Z4之任一者或二者表示-N=,以及其它者表示-CH=;Y表示氧原子、硫原子、視需要經取代之亞甲基或-NRc-;Rc表示氫原子,或者取代基;以及R表示(1) 以下列化學式表示之基團:其中,R1表示苯基或5至10員雜環基,各該等基係視需要經取代;L表示硫原子、氧原子、視需要經取代之亞甲基、-CO-、-NRa-、-CH2O-、-NRaCOO-、-NRaCONRb-、-NRaCOCH2-、-NRaCO-、Ra及Rb為相同或不同,且各自表示氫原子,或者視需要經取代之C1-6烷基,或者L及R1組合而視需要形成視需要經取代之二或三環之稠和雜環基;以及環B1表示苯環、吡啶環、嘧啶環、吡環或嗒環,且各該等
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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