The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.本發明關於VEGF結合劑類、DLL4結合劑類、VEGF/DLL4雙特異性結合劑類及使用該等劑類治療疾病(諸如癌)之方法。本發明提供與人VEGF特異性結合之抗體類、與人DLL4特異性結合之抗體類及與人VEGF及/或人DLL4特異性結合之雙特異性抗體類。本發明另提供使用該等劑類抑制腫瘤生長之方法。本發明亦描述治療癌之方法,該等方法包含對患有腫瘤或癌之病患投予治療有效量之本發明之劑或抗體。
