[Problem] To provide: a Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an anti-angiogenic agent, an agent for maturing blood vessels, an agent for normalizing blood vessels and an agent for stabilizing blood vessels, which are highly safe and respectively have excellent Tie2 activating effect, vascular endothelial growth factor (VEGF) inhibitory effect, anti-angiogenic effect, blood vessel maturing effect, blood vessel normalizing effect and blood vessel stabilizing effect and a pharmaceutical composition. [Solution] A Tie2 activator, a vascular endothelial growth factor (VEGF) inhibitor, an anti-angiogenic agent, an agent for maturing blood vessels, an agent for normalizing blood vessels and an agent for stabilizing blood vessels, each of which contains, as an active ingredient, at least one extract selected from among a hawthorn extract, a star fruit extract, a light galangal extract, an Indian lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a quillai extract, a kohki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a wolfberry extract, a chamomile extract and a butchers broom extract and a pharmaceutical composition.Linvention vise à fournir: un activateur de Tie2, un inhibiteur du facteur de croissance vasculaire endothélial (VEGF), un agent anti-angiogénique, un agent pour la maturation des vaisseaux sanguins, un agent pour la normalisation des vaisseaux sanguins et un agent pour la stabilisation des vaisseaux sanguins, qui sont hautement sûrs et, respectivement ont un excellent effet activateur de Tie2, un excellent effet inhibiteur du facteur de croissance vasculaire endothélial (VEGF), un excellent effet anti-angiogénique, un excellent effet de maturation des vaisseaux sanguins, un excellent effet de normalisation des vaisseaux sanguins et un excellent effet de stabilisation des vaisseaux sang
