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PROCÉDÉ DE PRODUCTION DE (1S,4S,5S)-4-BROMO-6- OXABICYCLO[3.2.1]OCTANE-7-ONE
专利权人:
Daiichi Sankyo Co.; Ltd.
发明人:
申请号:
EP14774738.0
公开号:
EP2980090A1
申请日:
2014.03.28
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
It is an object of the present invention to provide a method for efficiently producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which is important as an intermediate compound for the production of an FXa-inhibiting compound. A method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which comprises treating an (R)-α-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo-5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.
来源网站:
中国工程科技知识中心
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