PROCÉDÉ DE PRODUCTION DE (1S,4S,5S)-4-BROMO-6- OXABICYCLO[3.2.1]OCTANE-7-ONE

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专利权人:

Daiichi Sankyo Co.; Ltd.

发明人:

申请号：

EP14774738.0

公开号：

EP2980090A1

申请日:

2014.03.28

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

It is an object of the present invention to provide a method for efficiently producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which is important as an intermediate compound for the production of an FXa-inhibiting compound. A method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which comprises treating an (R)-α-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo-5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.

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