production method of a compound

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专利权人:

DAIICHI SANKYO COMPANY; LIMITED

发明人:

Yoshihiro Takayanagi,Yoshitaka Nakamura,Yukito Furuya

申请号：

BR112015019669

公开号：

BR112015019669A2

申请日:

2014.03.28

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 Summary "Production Method of a Compound" The present invention addresses the problem of providing a production method of (1s, 4s, 5s) -4 -bromo-6-oxabicyclo [3,2,1] octan-7-one (1), which is important as an intermediate compound for the production of a high efficiency fxa inhibitor compound. a method of producing (1s, 4s, 5s) -4-bromo-6-oxabicyclo [3,2,1] octan-7-one (1), said method being characterized by treating a (r) -Î ± -phenylethylamine (3) -cyclohexene-1-carboxylic acid salt with 1,3-dibromo-5,5-dimethylidantoin or n-bromosuccinimide in a solvent.1 / 1 resumo “mã‰todo de produã‡ãƒo de um compostoâ€� a presente invenã§ã£o trata o problema de fornecer um mã©todo de produã§ã£o de (1s,4s,5s)-4-bromo-6-oxabiciclo[3,2,1]octan-7-ona (1), que ã© importante como um composto intermediã¡rio para a produã§ã£o de um composto inibidor de fxa, com alta eficiãªncia. um mã©todo de produã§ã£o de (1s,4s,5s)-4-bromo-6-oxabiciclo[3,2,1]octan-7-ona (1), o dito mã©todo sendo caracterizado pelo tratamento de um sal de (r)-î±-feniletilamina do ã¡cido (s)- 3-cicloexeno-1-carboxã­lico com 1,3-dibromo-5,5-dimetilidantoã­na ou n- bromossuccinimida em um solvente.

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