The United States of America; Dept. of Health and Human Services; as Represented by the Secretary
发明人:
Michael J. Lenardo,Jian Li,Lixin Zheng,Jae W. Lee,Wei Lu
申请号：
US15556738
公开号：
US20180105566A1
申请日:
2016.03.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins.
