GLYCOPROTEINE D'OLIGODENDROCYTE DE LA MYELINE, PROTEINE BASIQUE DE LA MYELINE, ET COMPOSITIONS DE PROTEINE PROTEOLIPIDIQUE AINSI QUE PROCEDE D'UTILISATION
THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
LENARDO, MICHAEL J.,LI, JIAN,ZHENG, LIXIN,LEE, JAE W.,LU, WEI
申请号：
CA2979038
公开号：
CA2979038A1
申请日:
2016.03.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins.
